Natural mixtures of POPs affected body weight gain and induced transcription of genes involved in weight regulation and insulin signaling
Identifieur interne : 000366 ( Main/Exploration ); précédent : 000365; suivant : 000367Natural mixtures of POPs affected body weight gain and induced transcription of genes involved in weight regulation and insulin signaling
Auteurs : Jan L. Lyche [Norvège] ; Rasoul Nourizadeh-Lillabadi [Norvège] ; Camilla Karlsson [Norvège] ; Benedicte Stavik [Norvège] ; Vidar Berg [Norvège] ; Janneche Utne Skare [Norvège] ; Peter Alestr M [Norvège] ; Erik Ropstad [Norvège]Source :
- Aquatic toxicology [ 0166-445X ] ; 2011.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Milieu aquatique.
English descriptors
- KwdEn :
Abstract
Obesity is reaching epidemic proportions worldwide, and is associated with chronic illnesses such as diabetes, cardiovascular disease, hypertension and dyslipidemias (metabolic syndrome). Commonly held causes of obesity are overeating coupled with a sedentary lifestyle. However, it has also been postulated that exposure to endocrine disrupting chemicals (EDCs) may be related to the significant increase in the prevalence of obesity and associated diseases. In the present study, developmental and reproductive effects of lifelong exposure to environmentally relevant concentrations of two natural mixtures of persistent organic pollutants (PoPs) were investigated using classical and molecular methods in a controlled zebrafish model. The mixtures used were extracted from burbot (Lota lota) liver originating from freshwater systems in Norway (Lake Mjøsa and Lake Losna). The concentration of POPs in the zebrafish ranged from levels detected in wild fish (Lake Mjøsa and Lake Losna), to concentrations reported in human and wildlife populations. Phenotypic effects observed in both exposure groups included (1) earlier onset of puberty, (2) elevated male/female sex ratio, and (3) increased body weight at 5 months of age. Interestingly, genome-wide transcription profiling identified functional networks of genes, in which key regulators of weight homeostasis (PPARs, glucocoricoids, CEBPs, estradiol), steroid hormone functions (glucocoricoids, estradiol, NCOA3) and insulin signaling (HNF4A, CEBPs, PPARG) occupied central positions. The increased weight and the regulation of genes associated with weight homeostasis and insulin signaling observed in the present study suggest that environmental pollution may affect the endocrine regulation of the metabolism, possibly leading to increased weight gain and obesity.
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Lyche</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Dept. Production Animal Clinical Science, Norwegian School of Veterinary Science, POB 8146 Dep.</s1><s2>0033 Oslo</s2><s3>NOR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Norvège</country><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Dept. Food safety and Infection Biology, Norwegian School of Veterinary Science, POB 8146 Dep.</s1><s2>0033 Oslo</s2><s3>NOR</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Norvège</country><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Nourizadeh Lillabadi, Rasoul" sort="Nourizadeh Lillabadi, Rasoul" uniqKey="Nourizadeh Lillabadi R" first="Rasoul" last="Nourizadeh-Lillabadi">Rasoul Nourizadeh-Lillabadi</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Dept. of Basic Sciences and Aquatic Medicine, Norwegian School of Veterinary Science, POB 8146 Dep.</s1><s2>0033 Oslo</s2><s3>NOR</s3><sZ>2 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Norvège</country><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Karlsson, Camilla" sort="Karlsson, Camilla" uniqKey="Karlsson C" first="Camilla" last="Karlsson">Camilla Karlsson</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Dept. Production Animal Clinical Science, Norwegian School of Veterinary Science, POB 8146 Dep.</s1><s2>0033 Oslo</s2><s3>NOR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Norvège</country><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Stavik, Benedicte" sort="Stavik, Benedicte" uniqKey="Stavik B" first="Benedicte" last="Stavik">Benedicte Stavik</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Medical Genetics, Oslol University Hospital, Kirkeveien 166</s1><s2>0407 Oslo</s2><s3>NOR</s3><sZ>4 aut.</sZ></inist:fA14><country>Norvège</country><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Berg, Vidar" sort="Berg, Vidar" uniqKey="Berg V" first="Vidar" last="Berg">Vidar Berg</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Dept. Food safety and Infection Biology, Norwegian School of Veterinary Science, POB 8146 Dep.</s1><s2>0033 Oslo</s2><s3>NOR</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Norvège</country><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Utne Skare, Janneche" sort="Utne Skare, Janneche" uniqKey="Utne Skare J" first="Janneche" last="Utne Skare">Janneche Utne Skare</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Dept. Food safety and Infection Biology, Norwegian School of Veterinary Science, POB 8146 Dep.</s1><s2>0033 Oslo</s2><s3>NOR</s3><sZ>1 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Norvège</country><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>National Veterinary Institute, POB 8156 Dep.</s1><s2>0033 Oslo</s2><s3>NOR</s3><sZ>6 aut.</sZ></inist:fA14><country>Norvège</country><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Alestr M, Peter" sort="Alestr M, Peter" uniqKey="Alestr M P" first="Peter" last="Alestr M">Peter Alestr M</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Dept. of Basic Sciences and Aquatic Medicine, Norwegian School of Veterinary Science, POB 8146 Dep.</s1><s2>0033 Oslo</s2><s3>NOR</s3><sZ>2 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Norvège</country><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author><author><name sortKey="Ropstad, Erik" sort="Ropstad, Erik" uniqKey="Ropstad E" first="Erik" last="Ropstad">Erik Ropstad</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Dept. Production Animal Clinical Science, Norwegian School of Veterinary Science, POB 8146 Dep.</s1><s2>0033 Oslo</s2><s3>NOR</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Norvège</country><placeName><settlement type="city">Oslo</settlement><region nuts="2">Østlandet</region></placeName></affiliation></author></analytic><series><title level="j" type="main">Aquatic toxicology</title><title level="j" type="abbreviated">Aquat. toxicol.</title><idno type="ISSN">0166-445X</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Aquatic toxicology</title><title level="j" type="abbreviated">Aquat. toxicol.</title><idno type="ISSN">0166-445X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aquatic environment</term><term>Body weight</term><term>Ecotoxicology</term><term>Obesity</term><term>Persistent organic pollutant</term><term>Toxicity</term><term>Transcription</term><term>Weight gain</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Polluant organique persistant</term><term>Poids corporel</term><term>Prise poids</term><term>Transcription</term><term>Obésité</term><term>Milieu aquatique</term><term>Ecotoxicologie</term><term>Toxicité</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Milieu aquatique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Obesity is reaching epidemic proportions worldwide, and is associated with chronic illnesses such as diabetes, cardiovascular disease, hypertension and dyslipidemias (metabolic syndrome). Commonly held causes of obesity are overeating coupled with a sedentary lifestyle. However, it has also been postulated that exposure to endocrine disrupting chemicals (EDCs) may be related to the significant increase in the prevalence of obesity and associated diseases. In the present study, developmental and reproductive effects of lifelong exposure to environmentally relevant concentrations of two natural mixtures of persistent organic pollutants (PoPs) were investigated using classical and molecular methods in a controlled zebrafish model. The mixtures used were extracted from burbot (Lota lota) liver originating from freshwater systems in Norway (Lake Mjøsa and Lake Losna). The concentration of POPs in the zebrafish ranged from levels detected in wild fish (Lake Mjøsa and Lake Losna), to concentrations reported in human and wildlife populations. Phenotypic effects observed in both exposure groups included (1) earlier onset of puberty, (2) elevated male/female sex ratio, and (3) increased body weight at 5 months of age. Interestingly, genome-wide transcription profiling identified functional networks of genes, in which key regulators of weight homeostasis (PPARs, glucocoricoids, CEBPs, estradiol), steroid hormone functions (glucocoricoids, estradiol, NCOA3) and insulin signaling (HNF4A, CEBPs, PPARG) occupied central positions. The increased weight and the regulation of genes associated with weight homeostasis and insulin signaling observed in the present study suggest that environmental pollution may affect the endocrine regulation of the metabolism, possibly leading to increased weight gain and obesity.</div></front></TEI><affiliations><list><country><li>Norvège</li></country><region><li>Østlandet</li></region><settlement><li>Oslo</li></settlement></list><tree><country name="Norvège"><region name="Østlandet"><name sortKey="Lyche, Jan L" sort="Lyche, Jan L" uniqKey="Lyche J" first="Jan L." last="Lyche">Jan L. Lyche</name></region><name sortKey="Alestr M, Peter" sort="Alestr M, Peter" uniqKey="Alestr M P" first="Peter" last="Alestr M">Peter Alestr M</name><name sortKey="Berg, Vidar" sort="Berg, Vidar" uniqKey="Berg V" first="Vidar" last="Berg">Vidar Berg</name><name sortKey="Karlsson, Camilla" sort="Karlsson, Camilla" uniqKey="Karlsson C" first="Camilla" last="Karlsson">Camilla Karlsson</name><name sortKey="Lyche, Jan L" sort="Lyche, Jan L" uniqKey="Lyche J" first="Jan L." last="Lyche">Jan L. Lyche</name><name sortKey="Nourizadeh Lillabadi, Rasoul" sort="Nourizadeh Lillabadi, Rasoul" uniqKey="Nourizadeh Lillabadi R" first="Rasoul" last="Nourizadeh-Lillabadi">Rasoul Nourizadeh-Lillabadi</name><name sortKey="Ropstad, Erik" sort="Ropstad, Erik" uniqKey="Ropstad E" first="Erik" last="Ropstad">Erik Ropstad</name><name sortKey="Stavik, Benedicte" sort="Stavik, Benedicte" uniqKey="Stavik B" first="Benedicte" last="Stavik">Benedicte Stavik</name><name sortKey="Utne Skare, Janneche" sort="Utne Skare, Janneche" uniqKey="Utne Skare J" first="Janneche" last="Utne Skare">Janneche Utne Skare</name><name sortKey="Utne Skare, Janneche" sort="Utne Skare, Janneche" uniqKey="Utne Skare J" first="Janneche" last="Utne Skare">Janneche Utne Skare</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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